This is one of the first studies of its kind to focus on younger men / photo: shutterstock/WeAre
Not getting enough shut-eye affects biomarkers associated with cardiovascular disease (CVD), according to a new study by researchers at Uppsala University in Sweden.
Many existing larger studies on the link between sleep deprivation and the risk of CVD focus on older individuals who already have an increased risk. This one, published in the Biomarker Research journal*, focused on men with an average age of 23.
According to the researchers, nearly half of Swedes regularly experience disturbed sleep and chronic lack of sleep is a growing public health concern.
Sleep lab tests Sixteen young men with an average BMI of 23 and healthy sleep habits spent time in a sleep laboratory where their meals and activity levels were controlled in two sessions.
In one session, the participants got a normal amount of sleep (8.5 hours) for three consecutive nights, while during the other session, they only had 4.25 hours of shut-eye.
Blood samples were collected during both sessions in the morning and evenings and following high-intensity 30-minute workouts. The samples were used to measure the levels of around 90 different proteins in the blood, looking at inflammation and increased risk of serious conditions such as heart failure and coronary artery disease.
Three-night difference The levels of proteins in the blood already linked to CVD increased after only three nights of sleep deprivation, despite participants previously being healthy.
“This means it’s important to emphasise the significance of sleep for CV health even in early life,” says study lead Jonathan Cedernaes, a physician and assistant professor at Uppsala University.
The researchers did note that after physical exercise, proteins linked to the positive effects of exercise increased whether the participant was sleep-deprived or not. They concluded that while exercise can offset some of the negative effects that poor sleep can cause, it cannot replace the overall health benefits of sleep.
Ongoing research will develop guidelines on how sleep, exercise and other lifestyle factors can be combined to prevent CVD.
*Brandao, LEM et al. The Overlooked Trio: Sleep Duration, Sampling Time and Physical Exercise Alter Levels of Olink-Assessed Blood Biomarkers of Cardiovascular Risk. Biomarker Research. 2025
Read more from this issue of Spa Business magazine
View contents of Spa Business 2025 issue 2
Editor’s letter: The Gen Z effect
With young adults reshaping our industry, affordable, community-based models are thriving, while traditional spas risk being left behind
Spa people: Novak Djokovic
Game, set, spa. The tennis star is poised to launch a biohacking pod while also entering a multi-year ambassador partnership with Aman
Spa people: Peter Attia
One of the most respected names in longevity medicine has co-founded preventative health clinic, Biograph
Spa people: Alexis Dean
The founder of Soak is on a mission to deliver social wellness without the hefty price tag across Australia
News report: Young influencers
Millennials and Gen Zers are redefining the wellness landscape according to new research by McKinsey
News report: Double vision
Fresh data from RLA Global reveals that hotels delivering wellness earn twice as much as those that don’t
Project preview: Laugarás Lagoon
Contrast bathing and fine dining are two USPs of a new geothermal destination in Iceland’s Golden Circle
Interview: Suzanne Holbrook
Marriott’s new global leader of spa, fitness and wellness talks candidly to Katie Barnes about her plans for the world’s largest hotel spa portfolio
Ask an expert: Vagus nerve
Insider insights into why this critical nerve is a key to wellbeing and how supportive treatments are set to shake up spa menus. Kath Hudson reports
Research: Marginally speaking
CBRE’s latest numbers show that spa revenues in US hotels have edged upward, profits have slipped slightly and costs are down
Investigation: Dealing with death
With a new openness emerging around the subject of end-of-life care, Julie Cramer investigates whether spas could offer death doula services
Trend: Head first
Judy Chapman tries out brain mapping at Gwinganna to see why it’s become so popular
First person: Relaxation rebooted
Does AI massage have a place in luxury spas? Cassandra Cavanah heads to The Ritz-Carlton Bacara, Santa Barbara to find out
Le Atelier by C.O.D.E. doesn't offer a standard bespoke service, it provides a highly
customised approach to designing massage beds and loungers in high-end wellness
environments. [more...]
+ More featured suppliers
COMPANY PROFILES
Klafs GmbH
Founded in 1928, Klafs is known as an award winning, world-leading trendsetter in wellness and spa. [more...]
Saskia Spa
Founded in 2014, Saskia Spa continues to evolve as a professional luxury skincare brand. It forms pa [more...]
This is one of the first studies of its kind to focus on younger men / photo: shutterstock/WeAre
Not getting enough shut-eye affects biomarkers associated with cardiovascular disease (CVD), according to a new study by researchers at Uppsala University in Sweden.
Many existing larger studies on the link between sleep deprivation and the risk of CVD focus on older individuals who already have an increased risk. This one, published in the Biomarker Research journal*, focused on men with an average age of 23.
According to the researchers, nearly half of Swedes regularly experience disturbed sleep and chronic lack of sleep is a growing public health concern.
Sleep lab tests Sixteen young men with an average BMI of 23 and healthy sleep habits spent time in a sleep laboratory where their meals and activity levels were controlled in two sessions.
In one session, the participants got a normal amount of sleep (8.5 hours) for three consecutive nights, while during the other session, they only had 4.25 hours of shut-eye.
Blood samples were collected during both sessions in the morning and evenings and following high-intensity 30-minute workouts. The samples were used to measure the levels of around 90 different proteins in the blood, looking at inflammation and increased risk of serious conditions such as heart failure and coronary artery disease.
Three-night difference The levels of proteins in the blood already linked to CVD increased after only three nights of sleep deprivation, despite participants previously being healthy.
“This means it’s important to emphasise the significance of sleep for CV health even in early life,” says study lead Jonathan Cedernaes, a physician and assistant professor at Uppsala University.
The researchers did note that after physical exercise, proteins linked to the positive effects of exercise increased whether the participant was sleep-deprived or not. They concluded that while exercise can offset some of the negative effects that poor sleep can cause, it cannot replace the overall health benefits of sleep.
Ongoing research will develop guidelines on how sleep, exercise and other lifestyle factors can be combined to prevent CVD.
*Brandao, LEM et al. The Overlooked Trio: Sleep Duration, Sampling Time and Physical Exercise Alter Levels of Olink-Assessed Blood Biomarkers of Cardiovascular Risk. Biomarker Research. 2025
Read more from this issue of Spa Business magazine
View contents of Spa Business 2025 issue 2
Editor’s letter: The Gen Z effect
With young adults reshaping our industry, affordable, community-based models are thriving, while traditional spas risk being left behind
Spa people: Novak Djokovic
Game, set, spa. The tennis star is poised to launch a biohacking pod while also entering a multi-year ambassador partnership with Aman
Spa people: Peter Attia
One of the most respected names in longevity medicine has co-founded preventative health clinic, Biograph
Spa people: Alexis Dean
The founder of Soak is on a mission to deliver social wellness without the hefty price tag across Australia
News report: Young influencers
Millennials and Gen Zers are redefining the wellness landscape according to new research by McKinsey
News report: Double vision
Fresh data from RLA Global reveals that hotels delivering wellness earn twice as much as those that don’t
Project preview: Laugarás Lagoon
Contrast bathing and fine dining are two USPs of a new geothermal destination in Iceland’s Golden Circle
Interview: Suzanne Holbrook
Marriott’s new global leader of spa, fitness and wellness talks candidly to Katie Barnes about her plans for the world’s largest hotel spa portfolio
Ask an expert: Vagus nerve
Insider insights into why this critical nerve is a key to wellbeing and how supportive treatments are set to shake up spa menus. Kath Hudson reports
Research: Marginally speaking
CBRE’s latest numbers show that spa revenues in US hotels have edged upward, profits have slipped slightly and costs are down
Investigation: Dealing with death
With a new openness emerging around the subject of end-of-life care, Julie Cramer investigates whether spas could offer death doula services
Trend: Head first
Judy Chapman tries out brain mapping at Gwinganna to see why it’s become so popular
First person: Relaxation rebooted
Does AI massage have a place in luxury spas? Cassandra Cavanah heads to The Ritz-Carlton Bacara, Santa Barbara to find out
The Ritz-Carlton, Langkawi, in Malaysia, has revealed a schedule for Global Wellness Day
(GWD) that includes guided rainforest walks, mindful movement and guided coastal meditation
experiences.
Longevitix, a clinical platform for preventive and longevity medicine, has launched its AI-
powered intelligence system to help physicians deliver continuous, personalised longevity-
focused care at scale.
Atmantan Wellness Centre, an integrative wellness destination in Mulshi, near Pune in India, is
expanding its portfolio by adding a new centre in Hyderabad that will launch between 2028 and
2029.
A recent survey by the UK Spa Association (UKSA) into the industry’s approach to cancer care
has revealed that almost half of participating respondents (46 per cent) are unaware that
cancer is a disability and guests with a cancer diagnosis must be given
Mexican operator, Solmar Hotels and Resorts, is hosting a series of events in celebration of
Global Wellness Day, including a Temazcal ceremony at its Playa Grande Resort and Spa in Los
Cabos.
Mandarin Oriental has announced a standalone residence brand, Mansions, which will debut at
Emirates Palace, Mandarin Oriental Mansions, Abu Dhabi, in 2029.
Four Seasons Resort The Nam Hai in Hoi An, Vietnam, has put together a Global Wellness Day
(GWD) agenda with activations rooted in nature and shaped by four pillars of Joy – in
alignment with the day’s theme #JoyMagenta.
The Global Wellness Summit (GWS) will celebrate its 20th anniversary at the 2026 event in
Phuket, Thailand, later this year with the theme: The Science, Art and Soul of Wellness.
Le Atelier by C.O.D.E. doesn't offer a standard bespoke service, it provides a highly
customised approach to designing massage beds and loungers in high-end wellness
environments. [more...]
+ More featured suppliers
COMPANY PROFILES
Klafs GmbH Founded in 1928, Klafs is known as an award winning, world-leading trendsetter in wellness and spa. [more...]
