A new anti-senescence serum from Biologique Recherche offers transformative results and raises the bar in anti-ageing skincare when combined with its iconic collagen formula
Sérum Progeskin’s formula combats signs of ageing / photo: Biologique Recherche
After nearly 50 years, Biologique Recherche has solidified its reputation for premium, high-performance skincare with its unique, clinical approach that consistently delivers both immediate and enduring results.
The latest innovation from the leading French skincare authority – Sérum Progeskin – represents the forefront of skin biology expertise, addressing one of the primary causes of skin ageing: cellular senescence.
Innovative defense Derived from the Latin “senescene” meaning ‘to grow old’, cellular senescence is a state where cells cease to divide but remain metabolically active. This process accelerates with natural ageing. Typically, cellular senescence occurs in response to damage, allowing tissue regeneration and the removal of dead cells. However, in ageing, damage often surpasses the repair capacity, leading to an accumulation of senescent cells.
These cells contribute to a pro-inflammatory environment that fosters age-related diseases and visible signs of ageing, such as thinning skin, flattened dermal-epidermal junctions, wrinkles, reduced elasticity and pigmentation issues.
The R&D teams at Biologique Recherche have focused on two key proteins involved in this process, firstly, Progerin, a protein that accumulates with age, disrupting cell regeneration, extracellular matrix integrity and inflammatory responses. This leads to thinning skin, wrinkles and loss of subcutaneous fat, resulting in a gaunt appearance typical of chronological ageing and secondly, Klotho. This is known as the ‘youth protein’ and maintains proper cell function by enhancing skin resistance to oxidative stress and blocking ageing pathways. Unlike progerin, klotho supports skin health and delays cell senescence.
Sérum Progeskin’s formula targets these proteins to combat ageing. Designed to be used around the face, neck and décolleté, it leaves the skin firmer, plumper and more toned, visibly reducing wrinkles and fine lines for a rejuvenated appearance.
Sérum Progeskin features a cutting-edge blend of two active ingredients: Progescence, which decreases progerin synthesis, reducing senescent cell accumulation over time and Pro-KL which activates klotho protein, supporting cellular metabolism and promoting skin cell longevity.
Potent partners For enhanced anti-ageing results, Biologique Recherche has paired Sérum Progeskin with its renowned Sérum Collagène Originel. This powerful combination addresses established wrinkles and preserves youthful skin.
Launched in 2022, Sérum Collagène Originel targets four primary types of collagen using Type 0 Collagen, silene extract, green microalgae, and soy glycopeptides. Type 0 Collagen, derived from marine jellyfish, is the purest form of collagen, representing the original protein in its raw state.
Working with a marine biotech specialist, Biologique Recherche’s R&D team extracted this ancient collagen to re-densify skin, making it tighter, smoother and plumper, while significantly reducing wrinkle length.
Sérum Collagène Originel specifically addresses established wrinkles, while Sérum Progeskin targets cutaneous ageing. Together, they provide a potent anti-ageing skincare solution.
Dr Philippe Allouche, co-chair and head of creation and R&D at Biologique Recherche, comments: “Sérum Progeskin and Sérum Collagène Originel work in synergy to preserve the skin’s natural youthfulness, delivering a firm and radiant complexion.”
About Biologique Recherche The science-led brand formulates its products without artificial fragrances in its own laboratory in France. Biologique Recherche is the partner of choice for exceptional spas, medical spas and premier luxury hotels in over 80 countries. Biologique Recherche has its own flagship Ambassades in Paris, Rome, Brussels, Stockholm, Shanghai and Los Angeles.
Progescence® and Pro-KL® are trademarks of Biologique Recherche
photo: Biologique Recherche
"Sérum Progeskin and Sérum Collagène Originel work in synergy to preserve the skin’s natural youthfulness" – Dr Philippe Allouche, Biologique Recherche
Read more from this issue of Spa Business magazine
View contents of Spa Business 2024 issue 3
Editor's letter: At a crossroads
As the UK prepares to host this year's Global Wellness Summit, fresh research shows its wellness industry must address a number of issues if it's to maintain levels of unprecedented growth
Spa People: Charlotte Church
The Welsh singer talks about how growing up in the media spotlight has influenced The Dreaming, her healing retreat business
Spa People: Julia Bradbury
Leading a series of Walk Yourself Happy retreats based on her best-selling book and years of TV presenting
Spa People: Samantha Dunn
Shaking up the industry with her new, affordable DIY consultancy programme for entrepreneurs
News report: Big spenders
Finn Partners’ latest research shows how China’s high-net-worth women are redefining luxury travel
News report: Step back in time
Two new GWI reports analyse the growth of the global spa and hot springs markets over the past 10 to 15 years
Interview: Dillip Rajakarier
Following a 450 per cent increase in core revenues, Minor Hotels is planning 200 more properties. Megan Whitby sits down with its CEO
New opening: Kintsugi Space
Patrizia Bortolin talks to Lisa Starr about creating a transformative women-only sanctuary in Abu Dhabi
Research: To inform and inspire
The UK Spa Association has conducted its first survey of spa businesses in the country for 18 years. GM Bobby Griffiths unveils the numbers
Research: From wellness to wellbeing
A new study uncovers four wellness consumer market segments ripe for innovation. WELLSurvey co-author Kevin Kelly reveals the findings in a Spa Business exclusive
First person: To the source
Jane Kitchen takes to the sulphurous waters of Terme di Saturnia in Italy and shares details about its exciting upcoming sister site in Milan
Promotion: L'OCCITANE en Provence – the art of recovery
With an approach to wellbeing that’s both holistic and grounded in science, the latest massage from L’OCCITANE en Provence promises to have a powerfully-beneficial effect on customers, both in the spa and at home
New opening: Surrenne at The Emory
The £15k memberships at this wellness club in London sold out in just weeks. Creator Inge Theron tells us why
First person: Playful wellness
A Stella McCartney facial and Tracy Anderson studio are just two USPs Megan Whitby finds at Surrenne
Promotion: TechnoAlpin – naturally cool design
TechnoAlpin’s snow technology is not only an effective way to introduce gentle cold therapy into the spa environment, it’s also a powerful biophilic design element that can bring the wonder of nature indoors
Promotion: Biologique Recherche – potent partnership
A new anti-senescence serum from Biologique Recherche offers transformative results and raises the bar in anti-ageing skincare when combined with its iconic collagen formula
Promotion: Comfort Zone – A longer life for skin
Created to combat the visible signs of ageing, Comfort Zone’s latest range revamp is based on the company’s pioneering research into cutaneous cellular longevity
Promotion: G.M. COLLIN – Clinical excellence in skincare
With laboratories based in Montreal, G.M. Collin’s highly researched derma-corrective treatments have been helping skincare professionals deliver exceptional and exclusive results worldwide for many decades. We talk to VP Myriam Sayer
A new anti-senescence serum from Biologique Recherche offers transformative results and raises the bar in anti-ageing skincare when combined with its iconic collagen formula
Sérum Progeskin’s formula combats signs of ageing / photo: Biologique Recherche
After nearly 50 years, Biologique Recherche has solidified its reputation for premium, high-performance skincare with its unique, clinical approach that consistently delivers both immediate and enduring results.
The latest innovation from the leading French skincare authority – Sérum Progeskin – represents the forefront of skin biology expertise, addressing one of the primary causes of skin ageing: cellular senescence.
Innovative defense Derived from the Latin “senescene” meaning ‘to grow old’, cellular senescence is a state where cells cease to divide but remain metabolically active. This process accelerates with natural ageing. Typically, cellular senescence occurs in response to damage, allowing tissue regeneration and the removal of dead cells. However, in ageing, damage often surpasses the repair capacity, leading to an accumulation of senescent cells.
These cells contribute to a pro-inflammatory environment that fosters age-related diseases and visible signs of ageing, such as thinning skin, flattened dermal-epidermal junctions, wrinkles, reduced elasticity and pigmentation issues.
The R&D teams at Biologique Recherche have focused on two key proteins involved in this process, firstly, Progerin, a protein that accumulates with age, disrupting cell regeneration, extracellular matrix integrity and inflammatory responses. This leads to thinning skin, wrinkles and loss of subcutaneous fat, resulting in a gaunt appearance typical of chronological ageing and secondly, Klotho. This is known as the ‘youth protein’ and maintains proper cell function by enhancing skin resistance to oxidative stress and blocking ageing pathways. Unlike progerin, klotho supports skin health and delays cell senescence.
Sérum Progeskin’s formula targets these proteins to combat ageing. Designed to be used around the face, neck and décolleté, it leaves the skin firmer, plumper and more toned, visibly reducing wrinkles and fine lines for a rejuvenated appearance.
Sérum Progeskin features a cutting-edge blend of two active ingredients: Progescence, which decreases progerin synthesis, reducing senescent cell accumulation over time and Pro-KL which activates klotho protein, supporting cellular metabolism and promoting skin cell longevity.
Potent partners For enhanced anti-ageing results, Biologique Recherche has paired Sérum Progeskin with its renowned Sérum Collagène Originel. This powerful combination addresses established wrinkles and preserves youthful skin.
Launched in 2022, Sérum Collagène Originel targets four primary types of collagen using Type 0 Collagen, silene extract, green microalgae, and soy glycopeptides. Type 0 Collagen, derived from marine jellyfish, is the purest form of collagen, representing the original protein in its raw state.
Working with a marine biotech specialist, Biologique Recherche’s R&D team extracted this ancient collagen to re-densify skin, making it tighter, smoother and plumper, while significantly reducing wrinkle length.
Sérum Collagène Originel specifically addresses established wrinkles, while Sérum Progeskin targets cutaneous ageing. Together, they provide a potent anti-ageing skincare solution.
Dr Philippe Allouche, co-chair and head of creation and R&D at Biologique Recherche, comments: “Sérum Progeskin and Sérum Collagène Originel work in synergy to preserve the skin’s natural youthfulness, delivering a firm and radiant complexion.”
About Biologique Recherche The science-led brand formulates its products without artificial fragrances in its own laboratory in France. Biologique Recherche is the partner of choice for exceptional spas, medical spas and premier luxury hotels in over 80 countries. Biologique Recherche has its own flagship Ambassades in Paris, Rome, Brussels, Stockholm, Shanghai and Los Angeles.
Progescence® and Pro-KL® are trademarks of Biologique Recherche
photo: Biologique Recherche
"Sérum Progeskin and Sérum Collagène Originel work in synergy to preserve the skin’s natural youthfulness" – Dr Philippe Allouche, Biologique Recherche
Read more from this issue of Spa Business magazine
View contents of Spa Business 2024 issue 3
Editor's letter: At a crossroads
As the UK prepares to host this year's Global Wellness Summit, fresh research shows its wellness industry must address a number of issues if it's to maintain levels of unprecedented growth
Spa People: Charlotte Church
The Welsh singer talks about how growing up in the media spotlight has influenced The Dreaming, her healing retreat business
Spa People: Julia Bradbury
Leading a series of Walk Yourself Happy retreats based on her best-selling book and years of TV presenting
Spa People: Samantha Dunn
Shaking up the industry with her new, affordable DIY consultancy programme for entrepreneurs
News report: Big spenders
Finn Partners’ latest research shows how China’s high-net-worth women are redefining luxury travel
News report: Step back in time
Two new GWI reports analyse the growth of the global spa and hot springs markets over the past 10 to 15 years
Interview: Dillip Rajakarier
Following a 450 per cent increase in core revenues, Minor Hotels is planning 200 more properties. Megan Whitby sits down with its CEO
New opening: Kintsugi Space
Patrizia Bortolin talks to Lisa Starr about creating a transformative women-only sanctuary in Abu Dhabi
Research: To inform and inspire
The UK Spa Association has conducted its first survey of spa businesses in the country for 18 years. GM Bobby Griffiths unveils the numbers
Research: From wellness to wellbeing
A new study uncovers four wellness consumer market segments ripe for innovation. WELLSurvey co-author Kevin Kelly reveals the findings in a Spa Business exclusive
First person: To the source
Jane Kitchen takes to the sulphurous waters of Terme di Saturnia in Italy and shares details about its exciting upcoming sister site in Milan
Promotion: L'OCCITANE en Provence – the art of recovery
With an approach to wellbeing that’s both holistic and grounded in science, the latest massage from L’OCCITANE en Provence promises to have a powerfully-beneficial effect on customers, both in the spa and at home
New opening: Surrenne at The Emory
The £15k memberships at this wellness club in London sold out in just weeks. Creator Inge Theron tells us why
First person: Playful wellness
A Stella McCartney facial and Tracy Anderson studio are just two USPs Megan Whitby finds at Surrenne
Promotion: TechnoAlpin – naturally cool design
TechnoAlpin’s snow technology is not only an effective way to introduce gentle cold therapy into the spa environment, it’s also a powerful biophilic design element that can bring the wonder of nature indoors
Promotion: Biologique Recherche – potent partnership
A new anti-senescence serum from Biologique Recherche offers transformative results and raises the bar in anti-ageing skincare when combined with its iconic collagen formula
Promotion: Comfort Zone – A longer life for skin
Created to combat the visible signs of ageing, Comfort Zone’s latest range revamp is based on the company’s pioneering research into cutaneous cellular longevity
Promotion: G.M. COLLIN – Clinical excellence in skincare
With laboratories based in Montreal, G.M. Collin’s highly researched derma-corrective treatments have been helping skincare professionals deliver exceptional and exclusive results worldwide for many decades. We talk to VP Myriam Sayer
People taking GLP-1 weight loss medications such as Ozempic, Wegovy, Mounjaro and Zepbound
may be losing weight, but they’re also becoming less physically active, according to new
research presented at the ENDO 2026 annual meeting of the Endocrine Society
Abu Dhabi-based investment firm Mubadala Capital has made a binding, fully financed
€1 billion
offer to acquire Pierre and Vacances SA, the European holiday resort operator behind the
continental European Center Parcs business.
Global retreat trade show, Synergy The Retreat Show, has launched a resource called The
Source, which hosts an open-access online Transformation Series programme.
The Standards Authority for Touch in Cancer Care (SATCC) charity has announced its first five-
day Living with Cancer and Beyond retreat, which will be held at Carden Park Hotel and Spa in
Cheshire, UK, between 1 and 5 September.
Patmos Aktis, a Luxury Collection Resort and Spa, has opened in Greece, with a renovated and
rebranded wellness offering called Ansana Wellness and Spa.
The Mauna Kea Beach Hotel, an Autograph Collection property in Hawaii, US, has opened its
22,000 sq ft indoor-outdoor Spa at Mauna Kea as the final step in the property’s overall
renovation, which has cost more than US$180 million (€166 million, £140 mill
The UK spa review and discovery platform for consumers, the Good Spa Guide, has announced
it will host the Good Spa Guide Awards 2026 during an event on 16 November at Sopwell House
Hotel in St Albans, UK.
Eighty-four per cent of consumers now say wellness is a top priority in their lives, with this
percentage increasing year on year, according to a preview presentation of McKinsey’s Future of
Wellness 2026 research report.
Mass protests have been taking place since Monday 1 June in Albania over the development of
a luxury resort by Donald Trump’s daughter Ivanka Trump and her husband Jared Kushner.
Global Wellness Day (GWD) marked its 15th anniversary on Saturday 13 June 2026, with the
theme: #JoyMagenta – a celebration of the healing qualities of simple gestures and activities
that spark joy.
