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Biologique Recherche

Skincare specialist, Biologique Recherche, is using its knowledge of chronobiology to create new approaches to skincare which yield powerful results


Biologique Recherche has a long commitment to customising its wide range of skincare products to the needs of the individual, including the use of DNA testing for diagnostics, to guide the prescription of treatments.

Now the company is adding the study of Chronobiology to its raft of prescription sciences.

Chronobiology – the scientific field that studies biorhythms – reveals the way the body responds to environmental variations that occur over time.

Three major cycles impact skin physiology. The first two – the nycthemeral and circadian cycles – are highly connected and last 24 hours on average. The third, the menstrual cycle, lasts around 28 days.

In order to establish the perfect times of day to use specific skin products to ensure optimum efficacy, the R&D team at Biologique Recherche, reviewed the science relating to the function of the skin to find out how it responds to these biological rhythms.

They found, for example, that the skin protects itself against environmental stressors during the day and repairs itself at night.

Thanks to this insight, the researchers have been able to determine the optimum time to apply products to get the best results.

“Chronobiology is very complex science and requires real expertise when determining a skincare routine, as it will depend on each person’s individual profile and each personalised skincare routine,” says Benjamin Choquenet PhD, R&D project manager at Biologique Recherche. “We asked ourselves, how can we improve our diagnoses? How can we improve the efficacy of our products?”

The method
Clients’ skin is assessed using the Biologique Recherche Skin Instant© Lab, a medical device which analyses the skin, diagnoses its condition and then prescribes products and treatments.

The Lab’s three-step methodology begins with an evaluation of the skin by expert therapists. This is followed by the taking of a series of measurements using five probes connected to a computer to measure moisture content, trans-epidermal water loss, skin elasticity, melanin and sebum content.

The combination of the results generates a personalised, dermo-cosmetic file, which enables therapists to make a customised selection of Biologique Recherche products and treatments, specifically tailored for each client.

This approach also gives clients the tools to be involved actively in their own treatment and because the right products are selected for each ‘diagnosis’, they get results.

Pierre-Louis Delapalme, co-président of Biologique Recherche, says: “Every time the guest comes to us, we assess their skin and identify how it’s changed. Your skin will have changed every time you come back to us, depending on the levels of stress you’re experiencing, what you eat, your hormonal cycle – there are so many reasons why your skin can change.

“Biologique Recherche spas keep a personalised history for guests, monitoring changes over time, so recommendations can be dynamically adjusted for each of them, to create a long-term treatment programme.

“Many people think the cosmetic industry is an ingredient battle – what’s new, what’s best etc,” he says. “We work differently, because our main source of inspiration is understanding the skin’s function.”

"Our main source of inspiration is understanding the skin’s functioning" – Pierre-Louis Delapalme, co-président

www.biologique-recherche.com

Perfect product
What to use and when to use it

• Products that act on the skin barrier, such as the lipid-replenishing Crème Dermo-RL, should be applied in the morning to protect the skin, or in cases of dermatitis, in the evening, to strengthen the skin and limit itching.

• Anti-redness products, such as the new Crème Verte Espoir A.R., are more effective when applied around noon and during the evening – to avoid the bloodflow spikes that occur during the afternoon and late evening.

• Products that act on sensitivity, such as Serum Biosensible, should be applied during the evening – the time of day when the skin is the most reactive.

• Products that act on the deeper layers of the skin should also be applied during the evening, when cutaneous penetration is maximal.

• An anti-aging product which acts on most skin cells, La Grande Crème is best applied in the evening, when cell proliferation is most active.

• When cleansing sensitive skin, scientists recommend this is done in the morning, to limit irritation and at night to remove the pollution of the day, with a sensitive product such as Eau Micellaire Biososensible.

• They recommend slimming products, such as Crème Anti-C, are applied either after meals, to limit fat storage in the body, or before exercise, to stimulate the breakdown of body fat.

• Exfoliating products such as Lotion P50 are recommended for use in the morning on sensitive skin, as it’s better protected at this time of day. On less sensitive skin, it can be applied in the morning and evening.

• At night, AHA and BHA acids in exfoliating products act on the surface of the skin and penetrate deeply into the epidermis, stimulating the production and renewal of skin cells.

Scientists at Biologique Recherche have established the best time to apply a wide range of skincare products for optimum results

Read more from this issue of Spa Business magazine

View contents of Spa Business 2020 issue 4
Products are developed in-house by an R&D team of scientists
Products are developed in-house by an R&D team of scientists
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CATALOGUE GALLERY
 

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DIRECTORY
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DIARY

 

23-26 Aug 2026

Elevate Spa Riviera Maya Edition

The Riviera Maya Edition Kanai, Playa del Carmen, Mexico
31 Aug - 02 Sep 2026

SpaTec North America

Pier Sixty Six, Fort Lauderdale, United States
+ More diary  
 
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©Cybertrek 2026
Uniting the world of spa & wellness
Get Spa Business and Spa Business insider digital magazines FREE
Sign up here ▸
News   Products   Magazine   Subscribe
Promotion
Biologique Recherche

Skincare specialist, Biologique Recherche, is using its knowledge of chronobiology to create new approaches to skincare which yield powerful results


Biologique Recherche has a long commitment to customising its wide range of skincare products to the needs of the individual, including the use of DNA testing for diagnostics, to guide the prescription of treatments.

Now the company is adding the study of Chronobiology to its raft of prescription sciences.

Chronobiology – the scientific field that studies biorhythms – reveals the way the body responds to environmental variations that occur over time.

Three major cycles impact skin physiology. The first two – the nycthemeral and circadian cycles – are highly connected and last 24 hours on average. The third, the menstrual cycle, lasts around 28 days.

In order to establish the perfect times of day to use specific skin products to ensure optimum efficacy, the R&D team at Biologique Recherche, reviewed the science relating to the function of the skin to find out how it responds to these biological rhythms.

They found, for example, that the skin protects itself against environmental stressors during the day and repairs itself at night.

Thanks to this insight, the researchers have been able to determine the optimum time to apply products to get the best results.

“Chronobiology is very complex science and requires real expertise when determining a skincare routine, as it will depend on each person’s individual profile and each personalised skincare routine,” says Benjamin Choquenet PhD, R&D project manager at Biologique Recherche. “We asked ourselves, how can we improve our diagnoses? How can we improve the efficacy of our products?”

The method
Clients’ skin is assessed using the Biologique Recherche Skin Instant© Lab, a medical device which analyses the skin, diagnoses its condition and then prescribes products and treatments.

The Lab’s three-step methodology begins with an evaluation of the skin by expert therapists. This is followed by the taking of a series of measurements using five probes connected to a computer to measure moisture content, trans-epidermal water loss, skin elasticity, melanin and sebum content.

The combination of the results generates a personalised, dermo-cosmetic file, which enables therapists to make a customised selection of Biologique Recherche products and treatments, specifically tailored for each client.

This approach also gives clients the tools to be involved actively in their own treatment and because the right products are selected for each ‘diagnosis’, they get results.

Pierre-Louis Delapalme, co-président of Biologique Recherche, says: “Every time the guest comes to us, we assess their skin and identify how it’s changed. Your skin will have changed every time you come back to us, depending on the levels of stress you’re experiencing, what you eat, your hormonal cycle – there are so many reasons why your skin can change.

“Biologique Recherche spas keep a personalised history for guests, monitoring changes over time, so recommendations can be dynamically adjusted for each of them, to create a long-term treatment programme.

“Many people think the cosmetic industry is an ingredient battle – what’s new, what’s best etc,” he says. “We work differently, because our main source of inspiration is understanding the skin’s function.”

"Our main source of inspiration is understanding the skin’s functioning" – Pierre-Louis Delapalme, co-président

www.biologique-recherche.com

Perfect product
What to use and when to use it

• Products that act on the skin barrier, such as the lipid-replenishing Crème Dermo-RL, should be applied in the morning to protect the skin, or in cases of dermatitis, in the evening, to strengthen the skin and limit itching.

• Anti-redness products, such as the new Crème Verte Espoir A.R., are more effective when applied around noon and during the evening – to avoid the bloodflow spikes that occur during the afternoon and late evening.

• Products that act on sensitivity, such as Serum Biosensible, should be applied during the evening – the time of day when the skin is the most reactive.

• Products that act on the deeper layers of the skin should also be applied during the evening, when cutaneous penetration is maximal.

• An anti-aging product which acts on most skin cells, La Grande Crème is best applied in the evening, when cell proliferation is most active.

• When cleansing sensitive skin, scientists recommend this is done in the morning, to limit irritation and at night to remove the pollution of the day, with a sensitive product such as Eau Micellaire Biososensible.

• They recommend slimming products, such as Crème Anti-C, are applied either after meals, to limit fat storage in the body, or before exercise, to stimulate the breakdown of body fat.

• Exfoliating products such as Lotion P50 are recommended for use in the morning on sensitive skin, as it’s better protected at this time of day. On less sensitive skin, it can be applied in the morning and evening.

• At night, AHA and BHA acids in exfoliating products act on the surface of the skin and penetrate deeply into the epidermis, stimulating the production and renewal of skin cells.

Scientists at Biologique Recherche have established the best time to apply a wide range of skincare products for optimum results

Read more from this issue of Spa Business magazine

View contents of Spa Business 2020 issue 4
Products are developed in-house by an R&D team of scientists
Products are developed in-house by an R&D team of scientists
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Hot spring wellness community Ameyalli sells residences and breaks ground on resort and spa
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Synergy – The Retreat Show invites consumer and industry perspectives on retreats for research
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FEATURED SUPPLIERS

Elemis launches its first Red Light Mask, lighting the way to advanced skin health and restoration
Elemis has branched into LED skincare with the launch of its breakthrough Red Light Mask. [more...]

Zerobody Cryo: Starpool's contrast therapy solution
Contrast therapy, based on the alternation of hot and cold rituals, has become one of the most valued practices in the fields of wellness and recovery. [more...]
+ More featured suppliers  
COMPANY PROFILES
Phytomer

Founded in Brittany, France, in 1972 by Jean Gédouin, Phytomer is a family-owned company now in its [more...]
+ More profiles  
CATALOGUE GALLERY
+ More catalogues  

DIRECTORY
+ More directory  
DIARY

 

23-26 Aug 2026

Elevate Spa Riviera Maya Edition

The Riviera Maya Edition Kanai, Playa del Carmen, Mexico
31 Aug - 02 Sep 2026

SpaTec North America

Pier Sixty Six, Fort Lauderdale, United States
+ More diary  
 


ADVERTISE . CONTACT US

Leisure Media
Tel: +44 (0)1462 431385

©Cybertrek 2026

ABOUT LEISURE MEDIA
LEISURE MEDIA MAGAZINES
LEISURE MEDIA HANDBOOKS
LEISURE MEDIA WEBSITES
LEISURE MEDIA PRODUCT SEARCH
PRINT SUBSCRIPTIONS
FREE DIGITAL SUBSCRIPTIONS