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This is one of the first studies of its kind to focus on younger men / photo: shutterstock/WeAre
Not getting enough shut-eye affects biomarkers associated with cardiovascular disease (CVD), according to a new study by researchers at Uppsala University in Sweden.
Many existing larger studies on the link between sleep deprivation and the risk of CVD focus on older individuals who already have an increased risk. This one, published in the Biomarker Research journal*, focused on men with an average age of 23.
According to the researchers, nearly half of Swedes regularly experience disturbed sleep and chronic lack of sleep is a growing public health concern.
Sleep lab tests Sixteen young men with an average BMI of 23 and healthy sleep habits spent time in a sleep laboratory where their meals and activity levels were controlled in two sessions.
In one session, the participants got a normal amount of sleep (8.5 hours) for three consecutive nights, while during the other session, they only had 4.25 hours of shut-eye.
Blood samples were collected during both sessions in the morning and evenings and following high-intensity 30-minute workouts. The samples were used to measure the levels of around 90 different proteins in the blood, looking at inflammation and increased risk of serious conditions such as heart failure and coronary artery disease.
Three-night difference The levels of proteins in the blood already linked to CVD increased after only three nights of sleep deprivation, despite participants previously being healthy.
“This means it’s important to emphasise the significance of sleep for CV health even in early life,” says study lead Jonathan Cedernaes, a physician and assistant professor at Uppsala University.
The researchers did note that after physical exercise, proteins linked to the positive effects of exercise increased whether the participant was sleep-deprived or not. They concluded that while exercise can offset some of the negative effects that poor sleep can cause, it cannot replace the overall health benefits of sleep.
Ongoing research will develop guidelines on how sleep, exercise and other lifestyle factors can be combined to prevent CVD.
*Brandao, LEM et al. The Overlooked Trio: Sleep Duration, Sampling Time and Physical Exercise Alter Levels of Olink-Assessed Blood Biomarkers of Cardiovascular Risk. Biomarker Research. 2025
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Millennials and Gen Zers are redefining the wellness landscape according to new research by McKinsey
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Fresh data from RLA Global reveals that hotels delivering wellness earn twice as much as those that don’t
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Marriott’s new global leader of spa, fitness and wellness talks candidly to Katie Barnes about her plans for the world’s largest hotel spa portfolio
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Research: Marginally speaking
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This is one of the first studies of its kind to focus on younger men / photo: shutterstock/WeAre
Not getting enough shut-eye affects biomarkers associated with cardiovascular disease (CVD), according to a new study by researchers at Uppsala University in Sweden.
Many existing larger studies on the link between sleep deprivation and the risk of CVD focus on older individuals who already have an increased risk. This one, published in the Biomarker Research journal*, focused on men with an average age of 23.
According to the researchers, nearly half of Swedes regularly experience disturbed sleep and chronic lack of sleep is a growing public health concern.
Sleep lab tests Sixteen young men with an average BMI of 23 and healthy sleep habits spent time in a sleep laboratory where their meals and activity levels were controlled in two sessions.
In one session, the participants got a normal amount of sleep (8.5 hours) for three consecutive nights, while during the other session, they only had 4.25 hours of shut-eye.
Blood samples were collected during both sessions in the morning and evenings and following high-intensity 30-minute workouts. The samples were used to measure the levels of around 90 different proteins in the blood, looking at inflammation and increased risk of serious conditions such as heart failure and coronary artery disease.
Three-night difference The levels of proteins in the blood already linked to CVD increased after only three nights of sleep deprivation, despite participants previously being healthy.
“This means it’s important to emphasise the significance of sleep for CV health even in early life,” says study lead Jonathan Cedernaes, a physician and assistant professor at Uppsala University.
The researchers did note that after physical exercise, proteins linked to the positive effects of exercise increased whether the participant was sleep-deprived or not. They concluded that while exercise can offset some of the negative effects that poor sleep can cause, it cannot replace the overall health benefits of sleep.
Ongoing research will develop guidelines on how sleep, exercise and other lifestyle factors can be combined to prevent CVD.
*Brandao, LEM et al. The Overlooked Trio: Sleep Duration, Sampling Time and Physical Exercise Alter Levels of Olink-Assessed Blood Biomarkers of Cardiovascular Risk. Biomarker Research. 2025
Read more from this issue of Spa Business magazine
View contents of Spa Business 2025 issue 2
Editor’s letter: The Gen Z effect
With young adults reshaping our industry, affordable, community-based models are thriving, while traditional spas risk being left behind
Spa people: Novak Djokovic
Game, set, spa. The tennis star is poised to launch a biohacking pod while also entering a multi-year ambassador partnership with Aman
Spa people: Peter Attia
One of the most respected names in longevity medicine has co-founded preventative health clinic, Biograph
Spa people: Alexis Dean
The founder of Soak is on a mission to deliver social wellness without the hefty price tag across Australia
News report: Young influencers
Millennials and Gen Zers are redefining the wellness landscape according to new research by McKinsey
News report: Double vision
Fresh data from RLA Global reveals that hotels delivering wellness earn twice as much as those that don’t
Project preview: Laugarás Lagoon
Contrast bathing and fine dining are two USPs of a new geothermal destination in Iceland’s Golden Circle
Interview: Suzanne Holbrook
Marriott’s new global leader of spa, fitness and wellness talks candidly to Katie Barnes about her plans for the world’s largest hotel spa portfolio
Ask an expert: Vagus nerve
Insider insights into why this critical nerve is a key to wellbeing and how supportive treatments are set to shake up spa menus. Kath Hudson reports
Research: Marginally speaking
CBRE’s latest numbers show that spa revenues in US hotels have edged upward, profits have slipped slightly and costs are down
Investigation: Dealing with death
With a new openness emerging around the subject of end-of-life care, Julie Cramer investigates whether spas could offer death doula services
Trend: Head first
Judy Chapman tries out brain mapping at Gwinganna to see why it’s become so popular
First person: Relaxation rebooted
Does AI massage have a place in luxury spas? Cassandra Cavanah heads to The Ritz-Carlton Bacara, Santa Barbara to find out
Four Seasons Resort The Nam Hai in Hoi An, Vietnam, has put together a Global Wellness Day
(GWD) agenda with activations rooted in nature and shaped by four pillars of Joy – in
alignment with the day’s theme #JoyMagenta.
The Global Wellness Summit (GWS) will celebrate its 20th anniversary at the 2026 event in
Phuket, Thailand, later this year with the theme: The Science, Art and Soul of Wellness.
Auko, an all-inclusive development, is opening in Phong Nha in Vietnam in Q3 2026, with a
series of 30 tented eco-lodges and wellness hospitality operations by Lumina Wellbeing.
Therme Manchester’s 28-acre development, which will include interconnected glass pavilions
that measure 65,000sq m, will be the largest bathing and wellbeing attraction in the world once
complete, according to prof David Russell, CEO of Therme UK.
Naples Beach Club, a Four Seasons Resort, has opened a 2,800sq m spa called The Sanctuary,
with the design and concept inspired by the Native American people that populated Florida’s
Southwest coast – the Calusa.
Swire Hotels’ luxury hospitality brand Upper House has revealed it will roll out its two-day
House of Healing retreats at its three hotels in Hong Kong, Chengdu and Shanghai.
LVMH-owned beauty house Guerlain will launch up to five spas with partners a year as part of
its plan to expand globally, according to the brand’s international spa and wellness director,
Diane Davody.
A new global study by Kevin Kelly and Peter Yesawich, called WELLSurvey 2.0, has revealed
more than half of consumers in the UK, US and Germany would not choose numerous high-
profile wellness resort brands for a future trip.
Luxury hospitality and wellness pioneer Jeremy McCarthy has launched Leisure Alchemy, a
digital platform that will provide professionals with strategic guidance on how to build
transformational leisure experiences that drive profit.
