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111Skin supports partners with an in-depth education programme / photo: Toska European Spa in Coral Gables, FL
111SKIN is a market-leading brand created by world-renowned plastic and reconstructive surgeon Dr Yannis Alexandrides and CCO Eva Alexandridis. Marrying medical expertise with advanced skincare, the brand was born from a need to bridge the gap between plastic surgery and everyday skin health.
With more than 30 years’ experience and more than two decades of in-clinic practice at London’s 111 Harley St, Alexandrides leads 111Skin’s research and product development. He originally launched the brand in 2012 to offer clients post-surgical skincare solutions that were both effective and non-irritating – something he found lacking in existing clinical-strength products.
“Eva said, ‘If the right product doesn’t exist, then why not make it yourself?’ So, I did,” he recalls. From this vision, Alexandrides developed NAC Y2, his patented reparative complex, laying the foundation for 111Skin.
Leveraging his deep grasp of the epidermal structure, Alexandrides continues to push boundaries in skincare. His formulas incorporate next-generation actives designed for even the most sensitive skin, directly inspired by his experience with cutting-edge cosmetic technology and in-clinic treatments.
Making waves in spa 111Skin entered the spa industry in 2018 and swiftly established itself as a leader in science-backed, results-driven treatments. By merging Alexandrides’ medical expertise with clinic-inspired techniques and sensorial spa application, the brand has created a unique treatment philosophy – combining the luxury of a spa experience with the transformative results of 111 Harley St.
Rooted in both clinical and holistic wellness, the brand’s spa concept delivers indulgent treatment journeys while ensuring visible, lasting improvements to the skin.
Developed by Alexandrides and 111Skin’s global head aesthetician Milena Naydenov, these treatments integrate signature steps designed in the clinic to set new standards and revolutionise spa aesthetics.
Following Alexandrides’ 3D approach to aesthetics, the manual techniques work beyond the skin’s surface, engaging facial musculature to sculpt and renew for dramatic, sculpted results.
A global luxury presence From launching in premier spas at The Ritz-Carlton Hong Kong and Four Seasons Beverly Wilshire, 111Skin has expanded into over 100 elite locations worldwide. This includes a curated mix of medi-spas, renowned facialists, prestigious hotels, and over one-third of Forbes 5-Star Top 100 properties.
Partnering for success Science is at the heart of 111Skin, making education a cornerstone of its spa division. Comprehensive training ensures spa partners gain an in-depth understanding of the brand’s clinically advanced products and treatments. The education programme supports therapists and extended teams, including marketing and sales, with ongoing learning opportunities.
Beyond training, 111Skin fosters partnerships with generous incentives, gifting programmes and collaborative marketing support.
“At 111Skin, we pride ourselves on our hands-on approach with spa partners,” says Tom MacPherson Le Maire, director of global spa, clinic and distributors.
“We act as an extension of their team, offering best-in-class education, dynamic trade marketing, business development, PR and branding activations. Our goal is to grow together, aligning with our partners’ ambitions and helping them achieve them.”
Expanding horizons 111Skin boasts strong spa partnerships with leading operators, including Mandarin Oriental, Four Seasons, Accor Luxury, Marriott Luxury and Rosewood. And with exciting discussions underway, the brand is poised to further expand its spa/clinic concept globally. The brand plans to deepen its relationships with key hotel partners, with a strategic focus on North America and APAC.
“We see tremendous potential to develop new treatments and wellness concepts with our collaborators,” says MacPherson Le Maire. “Many of our core partners have plans to expand, and we aim to grow with them – sustainably and with purpose. We estimate an opportunity of another 30-40 hotel partners over the next 2-3 years.”
With a strong foundation and a clear vision for the future, 111Skin continues to evolve, shaping the next chapter of high-performance skincare in the luxury spa space.
"Our formulas are directly inspired by my hands-on clinical experience" – Dr Yannis Alexandrides
Read more from this issue of Spa Business magazine
View contents of Spa Business 2025 issue 1
Editor's letter: Auto spas
Fully automated, self-service spas are set to enter the market, presenting a disruptive opportunity for investors and operators
Spa People: Christian Louboutin
The fashion designer teams up with his personal trainer to create a Brain Edit retreat at his hotel in Portugal
Spa People: Julien Alfred
Exercise, endurance and resilience are the focus of a programme being led by Olympic 100m winner Julien Alfred at BodyHoliday in St Lucia
News report: Emerging economies
Two fresh GWI reports highlight the potential of the wellness markets in the Maldives and Saudi Arabia
Interview: Paul Hawco
Katie Barnes talks to the man heading up wellbeing at Banyan Group as it prepares to open its 100th resort and reports a 16 per cent rise in revenue
Wellness design: Design of the times
Sixteen experts share their insights on how wellness design can be used to create more impactful and profitable spas in a new white paper by Accor
Opinion: High leverage learning
What three skills do people need to master to future-proof their spa careers? Jeremy McCarthy reports
Spa tourism: Hot on the trail
A famous pilgrimage route and natural hot springs are being combined in an innovative tourism package in Spain
Opinion: Beacons of light
As cities in the US start to hire chief wellness officers, Mia Kyricos reveals what this means for our sector
Sponsored: 111SKIN - Winning formulation
111SKIN’s spa/clinic concept is making waves globally – backed by a combination of medical expertise, intuitive partner support and potent products
Product focus: AI and robot massage
Spas around the world are starting to offer AI massage. We highlight the different types of equipment coming to market
Menu engineering: At your service
A dedicated brain health facility at Kamalaya and a menopause package by actor Naomi Watts feature in our programming pages this issue
Finishing touch: Big business
Companies investing in workers’ happiness outperform other portfolios in major global stock markets, according to new research
111Skin supports partners with an in-depth education programme / photo: Toska European Spa in Coral Gables, FL
111SKIN is a market-leading brand created by world-renowned plastic and reconstructive surgeon Dr Yannis Alexandrides and CCO Eva Alexandridis. Marrying medical expertise with advanced skincare, the brand was born from a need to bridge the gap between plastic surgery and everyday skin health.
With more than 30 years’ experience and more than two decades of in-clinic practice at London’s 111 Harley St, Alexandrides leads 111Skin’s research and product development. He originally launched the brand in 2012 to offer clients post-surgical skincare solutions that were both effective and non-irritating – something he found lacking in existing clinical-strength products.
“Eva said, ‘If the right product doesn’t exist, then why not make it yourself?’ So, I did,” he recalls. From this vision, Alexandrides developed NAC Y2, his patented reparative complex, laying the foundation for 111Skin.
Leveraging his deep grasp of the epidermal structure, Alexandrides continues to push boundaries in skincare. His formulas incorporate next-generation actives designed for even the most sensitive skin, directly inspired by his experience with cutting-edge cosmetic technology and in-clinic treatments.
Making waves in spa 111Skin entered the spa industry in 2018 and swiftly established itself as a leader in science-backed, results-driven treatments. By merging Alexandrides’ medical expertise with clinic-inspired techniques and sensorial spa application, the brand has created a unique treatment philosophy – combining the luxury of a spa experience with the transformative results of 111 Harley St.
Rooted in both clinical and holistic wellness, the brand’s spa concept delivers indulgent treatment journeys while ensuring visible, lasting improvements to the skin.
Developed by Alexandrides and 111Skin’s global head aesthetician Milena Naydenov, these treatments integrate signature steps designed in the clinic to set new standards and revolutionise spa aesthetics.
Following Alexandrides’ 3D approach to aesthetics, the manual techniques work beyond the skin’s surface, engaging facial musculature to sculpt and renew for dramatic, sculpted results.
A global luxury presence From launching in premier spas at The Ritz-Carlton Hong Kong and Four Seasons Beverly Wilshire, 111Skin has expanded into over 100 elite locations worldwide. This includes a curated mix of medi-spas, renowned facialists, prestigious hotels, and over one-third of Forbes 5-Star Top 100 properties.
Partnering for success Science is at the heart of 111Skin, making education a cornerstone of its spa division. Comprehensive training ensures spa partners gain an in-depth understanding of the brand’s clinically advanced products and treatments. The education programme supports therapists and extended teams, including marketing and sales, with ongoing learning opportunities.
Beyond training, 111Skin fosters partnerships with generous incentives, gifting programmes and collaborative marketing support.
“At 111Skin, we pride ourselves on our hands-on approach with spa partners,” says Tom MacPherson Le Maire, director of global spa, clinic and distributors.
“We act as an extension of their team, offering best-in-class education, dynamic trade marketing, business development, PR and branding activations. Our goal is to grow together, aligning with our partners’ ambitions and helping them achieve them.”
Expanding horizons 111Skin boasts strong spa partnerships with leading operators, including Mandarin Oriental, Four Seasons, Accor Luxury, Marriott Luxury and Rosewood. And with exciting discussions underway, the brand is poised to further expand its spa/clinic concept globally. The brand plans to deepen its relationships with key hotel partners, with a strategic focus on North America and APAC.
“We see tremendous potential to develop new treatments and wellness concepts with our collaborators,” says MacPherson Le Maire. “Many of our core partners have plans to expand, and we aim to grow with them – sustainably and with purpose. We estimate an opportunity of another 30-40 hotel partners over the next 2-3 years.”
With a strong foundation and a clear vision for the future, 111Skin continues to evolve, shaping the next chapter of high-performance skincare in the luxury spa space.
"Our formulas are directly inspired by my hands-on clinical experience" – Dr Yannis Alexandrides
Read more from this issue of Spa Business magazine
View contents of Spa Business 2025 issue 1
Editor's letter: Auto spas
Fully automated, self-service spas are set to enter the market, presenting a disruptive opportunity for investors and operators
Spa People: Christian Louboutin
The fashion designer teams up with his personal trainer to create a Brain Edit retreat at his hotel in Portugal
Spa People: Julien Alfred
Exercise, endurance and resilience are the focus of a programme being led by Olympic 100m winner Julien Alfred at BodyHoliday in St Lucia
News report: Emerging economies
Two fresh GWI reports highlight the potential of the wellness markets in the Maldives and Saudi Arabia
Interview: Paul Hawco
Katie Barnes talks to the man heading up wellbeing at Banyan Group as it prepares to open its 100th resort and reports a 16 per cent rise in revenue
Wellness design: Design of the times
Sixteen experts share their insights on how wellness design can be used to create more impactful and profitable spas in a new white paper by Accor
Opinion: High leverage learning
What three skills do people need to master to future-proof their spa careers? Jeremy McCarthy reports
Spa tourism: Hot on the trail
A famous pilgrimage route and natural hot springs are being combined in an innovative tourism package in Spain
Opinion: Beacons of light
As cities in the US start to hire chief wellness officers, Mia Kyricos reveals what this means for our sector
Sponsored: 111SKIN - Winning formulation
111SKIN’s spa/clinic concept is making waves globally – backed by a combination of medical expertise, intuitive partner support and potent products
Product focus: AI and robot massage
Spas around the world are starting to offer AI massage. We highlight the different types of equipment coming to market
Menu engineering: At your service
A dedicated brain health facility at Kamalaya and a menopause package by actor Naomi Watts feature in our programming pages this issue
Finishing touch: Big business
Companies investing in workers’ happiness outperform other portfolios in major global stock markets, according to new research
Four Seasons Resort The Nam Hai in Hoi An, Vietnam, has put together a Global Wellness Day
(GWD) agenda with activations rooted in nature and shaped by four pillars of Joy – in
alignment with the day’s theme #JoyMagenta.
The Global Wellness Summit (GWS) will celebrate its 20th anniversary at the 2026 event in
Phuket, Thailand, later this year with the theme: The Science, Art and Soul of Wellness.
Auko, an all-inclusive development, is opening in Phong Nha in Vietnam in Q3 2026, with a
series of 30 tented eco-lodges and wellness hospitality operations by Lumina Wellbeing.
Therme Manchester’s 28-acre development, which will include interconnected glass pavilions
that measure 65,000sq m, will be the largest bathing and wellbeing attraction in the world once
complete, according to prof David Russell, CEO of Therme UK.
Naples Beach Club, a Four Seasons Resort, has opened a 2,800sq m spa called The Sanctuary,
with the design and concept inspired by the Native American people that populated Florida’s
Southwest coast – the Calusa.
Swire Hotels’ luxury hospitality brand Upper House has revealed it will roll out its two-day
House of Healing retreats at its three hotels in Hong Kong, Chengdu and Shanghai.
LVMH-owned beauty house Guerlain will launch up to five spas with partners a year as part of
its plan to expand globally, according to the brand’s international spa and wellness director,
Diane Davody.
A new global study by Kevin Kelly and Peter Yesawich, called WELLSurvey 2.0, has revealed
more than half of consumers in the UK, US and Germany would not choose numerous high-
profile wellness resort brands for a future trip.
Luxury hospitality and wellness pioneer Jeremy McCarthy has launched Leisure Alchemy, a
digital platform that will provide professionals with strategic guidance on how to build
transformational leisure experiences that drive profit.
